Alternate endings
There are two different endings in the game, depending on how the Little Sisters were treated. If more than one Little Sister was harvested, the "bad" ending will play. If no more than one Little Sister was harvested, but the rest were rescued, the "good" ending will play.

Restoring hacked robot's health
After hacking a robot, it will begin firing at your enemies. If the robot gets hit, it will begin to lose health, catch on fire, and eventually blow up. To stop this from happening, deactivate the robot (press A while pointing at the robot), then reactivate it a few seconds later. This should make the robot have full health again.

Hitting the jackpot at slot machine
Save the game before you start playing the slot machine. Then, keep reloading your saved game until you hit the jackpot.

Easy money
Use the Incinerate Plasmid on any slot machine to corrupt the machine. You will usually always win money when you use the burnt out machine.

Molotov cocktails
While normally the various alcoholic beverages (for example, Arcadia Merlot, Old Tom Whiskey, etc.) scattered throughout the game are used to recover health, they can be turned into Molotov cocktails similar to those used by the "Nitro Splicer" enemy. To do this, use a source of flame, such as the chemical thrower, the Incinerate! Plasmid, or an environmental source. Ignite the alcohol bottle, pick it up with the Telekinesis Plasmid, and throw it at the enemy of choice.

Easy kills
When you start, you will have the Wrench and the Electric Bolt Plasmid. Using these in rapid succession against most Splicers can often result in an efficient, quick kill. First, shock the Splicer. Before the convulsion ends, switch to the wrench, aim high, and hit the Splicer over the head. An efficient way of killing the Spider Splicers is to shoot a few clips of anti-personnel ammunition, preferably from the machine gun.

Finding Chompers' Dental key
The key to Chompers' Dental in the Medical Pavilion is acquired by using Telekinesis through the broken window to the left of the door. There should be a corpse hanging over the broken window. The key should be grabbed with Telekinesis because it is hanging on a wall on the other side of the window. You can get Telekinesis in an area near here. You will need to get that first, but do not follow the arrow back to the rubble that you need to get rid of until you explore Chompers' Dental. There is a safe and other good items inside. Note: Both Telekinesis and Chompers' Dental are near where you find the shotgun.

Reaching Atlas Fontaine's penthouse
The code to get to Atlas Fontaine's penthouse is "5744", which is in an Audio Diary.

Defeating Frank Fontaine
To defeat Frank Fontaine very fast, when you first enter the room, hit him with the tool the Little Sisters gave you. Fight him when he throws you off. Once he is back on the bed, run up and hit him again with the tool to drain his Adam. This works a lot faster due to him only having four or five jars of Adam to drain, and the fights are not very long afterwards.

Defeating security robots
If you are up against a stationary security robot (RPG, etc.), use Telekenesis to grab a crate or pallet. Hold it in front of you until you can find a place to hide and know what to do next. The item you hold up will block some attacks.

Pac-Man reference
In the Arcadia level, you will find a place that appears to be a bar. Search around a bit, and you will see a block of cheese, followed by holes. The cheese is cut like Pac-Man himself. There are holes next to it, none of which can be gun shots. If you shoot the floor with any weapon you have, the marks will not match.

Getting Little Sister Savior achievement
Do not harvest a single Little Sister throughout the game. Tenebaum will reward you with gifts (including Adam) every time you rescue three Little Sisters. This proves more effective, as you get the same amount of Adam as you would if you harvested them, but you also get the achievement.

Getting Tonic Collector achievement
When buying Plasmids, Tonics, and Upgrades from the Gatherer's Garden, always buy the Tonics first. Then, make sure you search every area for other Tonics. When you reach Point Prometheus, there will be three Tonics to find. The rest of the Tonics are available in the Gatherer's Garden. This will ensure you get the achievement. Note: To check how many Tonics you have, go to a Gene Bank, and count each "track".

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